Fig. 1

Flowchart diagram summarizing the genetic findings for singleton and twin fetuses with congenital heart defects. CHD, Congenital heart defect; CMA, Chromosomal microarray analysis; NCA, Numerical chromosomal abnormality; P/LP CNV, Pathogenic and likely pathogenic copy number variant; P/LP SV, Pathogenic and likely pathogenic sequence variant; ROH, Region of homozygosity; WES, Whole-exome sequencing. Other hits denoting cardiovascular phenotype-associated deleteriously rare variants in functionally intolerant genes