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Fig. 2 | Molecular Cytogenetics

Fig. 2

From: Loss of heterozygosity impacts MHC expression on the immune microenvironment in CDK12-mutated prostate cancer

Fig. 2

MHC high expressed in CDK12-altered prostate tumors are associated with the activation of immune-related pathways. Gene Set Enrichment Analysis (GSEA) of Hallmark pathways in MHC-I High pPCa (a) (n = 30), in MHC-II High pPCa (b) (n = 23), and of Hallmarks and Reactome pathways in MHC High mCRPC (n = 10) (c, d). A normalized enrichment score indicates each factor’s positive or negative association with the condition of interest, which means activation or suppression of the pathway. Enrichment analyses were performed using clusterProfiler and P-adjusted value = 0.05 as the cutoff. Enrichment scores for each comparison are described in Additional file 6: Tables S5 (MHC-I High pPCa), S6 (MHC-II High pPCa), and S7 (MHC-I High mCRPC)

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Molecular Cytogenetics

ISSN: 1755-8166