Fig. 3

MHC high expressed CDK12 defective prostate cancer showed enhanced expression of immunomodulatory genes. Normalized RNA-seq expression level of the following genes was found to be significant higher: a IDO1 (P < 0.018), b HAVCR2 (TIM3) (P < 0.0022) in CDK12-Mut MHC-I High (n = 48); c CD274 (PD-L1) (P < 0.0028), (d) HAVCR2 (TIM3) (P < 0.00012), (e) IDO1 (P < 0.001) in CDK12-Mut MHC-II High (n = 48); and (f) CD274 (PD-L1) (P < 0.0095) (n = 10). The statistical analysis revealed that p-values were less than 0.05 (*), and 0.01(**), respectively, as determined by the Mann–Whitney test. IDO1, Indoleamine 2,3-Dioxygenase 1; HAVCR3 (TIM3), T-Cell Immunoglobulin Mucin Receptor 3; CD274 (PD-L1), Programmed Cell Death 1 Ligand 1. The analysis used the low MHC group (Blue) as a control