Table 4 Comparison of clinical features and cytogenetic abnormalities in primary MDS in the West, S.E. Asia & Tunisia
Authors | This study | Schanz [15] | Haase [14] | Pozdnyakova [17] | Solé [16] | Berggren [18] | Miyazaki [19] | Wang [20] | Yan [21] | Li [33] | Qu [22] | Jung [23] | Gmidène [25] | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Country | India | Germany & Austria | USA | Spain | Sweden | EU & USA | Japan | China | China | China | China | Korea | Tunisia | |
Year | 2023 | 2012 | 2007-08 | 2009 | 2005 | 2018 | 2018 | 2018 | 2021 | 2021 | 2009 | 2012 | 2008 | 2008 |
Patients, n | 988 | 2902 | 2124 | 1029 | 968 | 1329 | 5838 | 300 | 655 | 634 | 351 | 532 | 231 | 224 |
Age, median (range) | 53 (18–86) | 70 (16–96) | 65.7 (0.1–96) | 67 (19–92) | 70 (1–94) | 75 (17–96) | 71 (40–106) | 65.5 (40–90) | 51 (6–86) | 57 (18–86) | 45 (16–79) | 48 (16–81) | 51 (18–84) | 60 (1–90) |
M: F ratio | 1.8:1 | 1.4:1 | 1.8:1 | 1.9:1 | 1.3:1 | 1.8:1 | 1.6:1 | 1.5:1 | 1.1:1 | 1.4:1 | 2.1:1 | 2:1 | 2:1 | 1.4:1 |
No. of KTs | 936 | 2801a | 2072b,^ | 1029 | 968c | 995d | 4844e.* | 261e,* | 665 | 634 | 351 | 532 | 231 | 224 |
Normal KT(%) | 45 | 55.1 | 47.7 | 55.5 | 53 | 49 | 62.7 | 65.5 | 55.2 | 61.4 | 32.5 | 35 | 49.8 | 47.2 |
Clonal abn (%) | 55 | 44.9 | 52.3^ | 44.5 | 47 | 51 | 37.3 | 34.5 | 44.8 | 38.6 | 67.5 | 65 | 50.2 | 52.8 |
Frequencies of individual abnormalities, % | ||||||||||||||
Der(1;7) | 0.9 | 0.3 | − | 0.6 | − | − | 0.3 | 1.9 | − | − | − | 1.9 | − | − |
Inv/t/del 3q | 0.96 | 0.4 | 2 | 0.3 | − | 0.1 | 0.4 | 0.8 | 0.8 | − | 0.8 | 1.9 | 0.9 | 0.4 |
5q− | 14.5 | 6.4 | 15.1 | 5.9 | 5.7 | 4 | 8.6 | 1.9 | 3.2 | 10.6** | 5.1** | 5.8 | 78 | 13 |
−7/ 7q− | 13.1/3 | 1.6/0.5 | 11.1 | 0.8/0.9 | 3/1.4 | 2 | 2.7/1.5 | 1.1/2.7 | 4.1 | 7.7 | 8.8 | 9 | 6.9 | 8 |
+ 8 | 11.5 | 4.7 | 3.7 | 5.8 | 5 | 5.8 | 3.8 | 11.3 | 12 | 19.1 | 20 | 17.3 | 3 | |
11q− | 2 | 0.7 | 1.1 | 0.5 | − | 0.4 | 1.2 | 1.1 | 1.2 | 2.7^^ | 2.6 | 1.9 | 0.9 | − |
12p− | 1.6 | 0.6 | 1.2 | 0.3 | − | 0.3 | 1.3 | 1.1 | − | 2.1 | 1.4 | 1.9 | 2.6 | 4 |
−13 / 13q− | 1.8/1.2 | 0.3 | 1.9 | − | − | − | 0.8 | 0.8 | − | 2.8 | − | 2.6 | − | 2 |
i(17)q | 0.9 | 0.4 | 2.6 with iso 17q | 0.2 | 1 | 0.2 | 0.3 | 0.8 | − | − | 3.8 | 3.2 | − | 1 |
−17/ 17p− | 3/0.5 | 0.2 | − | 0.5 | − | 0.6 | 1.1 | − | − | − | 2.6 | 2.6 | − | |
−18 | 3 | − | 3.8^^^ | − | − | − | − | − | − | 2.5 | 2.8 | 3.2 | − | − |
+ 19 | 1.6 | 0.4 | − | 0.4 | − | 0.2 | 0.5 | 0 | 0.5 | − | 2.8 | − | − | 0.4 |
20q− | 5.1 | 1.7 | 3.6 | 2.7 | 1.3 | 2 | 2.8 | 6.9 | 5.7 | 6.3 | 9.4 # | 7.8 | 6.5 | 3 |
+ 21 | 3.3 | − | 2.2 | − | − | − | 0.9 | − | 1.2 | − | 2.6 | 2.6 | 3.5 | 0.4 |
−Y | 2.6 | 2.2 | 2.8 | 2 | 1.8 | 5 | 3.4 | 1.1 | 2.3 | 2.2 | 2.3 | 2.6 | 2.6 | 0.4 |
No. of abnormalities in each karyotype, % | ||||||||||||||
Single abn | 29.8 | 28.7 | 29 | 26.9 | 35.9 | − | − | − | 36.5 | − | 54.8 | 38 | − | − |
Two abn | 7.5 | 6.2 | 9 | − | − | − | − | 22.8 | 11 | − | − | |||
IncC*** | 2.7 | 0.9 | − | − | − | − | − | − | − | − | − | − | − | − |
All CK**** | 15 | 9.1 | 14 | 17.6 | 11 | − | − | − | 8.3 | − | 22.4 | 16 | 15 | 8 |
CK,3 abn | 3.8 | 2.1 | 3 | − | − | − | − | − | − | − | − | 4 | − | − |
CK, > 3 abn | 11.2 | 7 | 11 | − | − | − | − | − | − | − | − | 12 | − | − |
Cytogenetic score (prognosis) categories, % | ||||||||||||||
n = 973 | n = 5838 | n = 300 | n = 532 | |||||||||||
Very good | 2 | 2.9 | − | − | − | 6 | 3.6 | 1 | 1.8 | − | − | 2 | − | − |
Good | 55.6**^ | 65.7 | − | − | − | 56 | 72.2 | 71.3 | 61.2 | − | − | 43 | − | − |
Intermediate | 16.2 | 19.2 | − | − | − | 15 | 13.3 | 17 | 25 | − | − | 36 | − | − |
Poor | 15 | 5.4 | − | − | − | 8 | 4.1 | 4.3 | 7.6 | − | − | 7 | − | − |
Very poor | 11.2 | 6.8 | − | − | − | 15 | 6.9 | 6.3 | 4.4 | − | − | 12 | − | − |
n = 842*^^ | n = 973 | n = 5838 | n = 300 | |||||||||||
Very low | 3.9 | − | − | − | − | 13 | 19.5 | 10 | − | − | − | − | − | − |
Low | 30.9 | − | − | − | − | 34 | 37.7 | 31.7 | − | − | − | − | − | − |
Intermediate | 24.2 | − | − | − | − | 20 | 19.2 | 32 | − | − | − | − | − | − |
High | 21 | − | − | − | − | 16 | 13.1 | 13.3 | − | − | − | − | − | − |
Very high | 20 | − | − | − | − | 17 | 10.5 | 13 | − | − | − | − | − | − |