Table 5 Comparison of clinical features and cytogenetic abnormalities in primary MDS in S.Asia
This study | Gupta [30] | Vundinti [29] | Anwar [35] | Mahmood [28] | Rashid [34] | |
|---|---|---|---|---|---|---|
Country | India | India | India | Pakistan | Pakistan | Pakistan |
Year | 2023 | 2017 | 2009 | 2017 | 2018 | 2014 |
No. of patients | 988 | 150 | 104/160* | 177 | 178 | 122 |
Age, median (range) | 53(18–86) | 55.5(2–87) | 44(5 mo-75) | 50(3–90) | 58(30–85) | 60(40–80) |
M: F ratio | 1.8:1 | 1.6:1 | 2.1:1 | 3.0:1 | 2.0:1 | 1.5:1 |
No. of karyotypes, | 936 | 86 | 104/160* | 98 | 178 | 71 |
Clonal abnormalities, % | 55.2 | 50 | 49 | 44 | 46.6 | 42.3 |
Frequencies of individual abnormalities, % | ||||||
Der (1;7) | 0.9 | − | − | − | − | − |
Inv/t/del 3q | 0.96 | − | − | − | − | − |
5q− | 14.5 | 3.5 | 5.8 | 6.1 | 7.3 | 2.8 |
−7/ 7q− | 13.1/3 | 16.3 | 12.5 | 7.1/2 | 6.7 (5.6/1.1) | −/4.2 |
+ 8 | 11.5 | 1.2 | 4.8 | 3.1 | 12.9 | 9.9 |
11q− | 2 | − | − | − | 2.8 | 1.4 |
12p− | 1.6 | − | − | − | − | − |
−13/13q− | 1.8/1.2 | − | − | − | − | − |
i(17)q | 0.9 | − | − | − | 0.6 | − |
−17/17p− | 3/0.5 | − | 2.9 | − | − | − |
−18 | 3 | − | − | − | − | − |
+ 19 | 15(1.6) | − | − | − | − | 1.4 |
20q− | 5.1 | 4.7 | 1.9 | 4 | 2.2 | 1.4 |
+ 21 | 3.3 | − | − | 1 | − | − |
−Y | 2.6 | − | − | − | 2.8 | 2.8 |
No. of abnormalities in each karyotype, % | ||||||
Single abnormality | 29.8 | 19.8 | − | − | 31.4 | 19.2 |
Double abnormalities | 7.5 | 8.1 | − | − | 4.5 | 6.7 |
IncC** | 2.7 | − | − | − | − | − |
All CK | 15 | 16.3 | − | 12 | 10.7 | 16.4 |
CK with 3 abnormalities | 3.8 | − | − | − | − | − |
CK with > 3 abnormalities | 11.2 | − | − | − | − | − |
Cytogenetic score (prognosis) categories, % | ||||||
Very good | 2 | 1.1 | − | − | 5.6 | − |
Good | 55.6*** | 56.9 | − | − | 62.9 | − |
Intermediate | 16.2 | 11.6 | − | − | 15.2 | − |
Poor | 15 | 13.9 | − | − | 12.9 | − |
Very poor | 11.2 | 16.2 | − | − | 3.4 | − |
Clinical (IPSS-R) risk groups, % | ||||||
Very low | 3.9 | 2.3 | − | − | 9.6 | − |
Low | 30.9 | 12.8 | − | − | 41 | − |
Intermediate | 24.2 | 29 | − | − | 27.1 | − |
High | 21 | 31.4 | − | − | 13.5 | − |
Very high | 20 | 24.4 | − | − | 9.1 | − |