Genomic landscape of childhood acute lymphoblastic leukemia in Malaysia: insights from array-CGH

Table 1 Pathogenic CNVs identified by array-CGH in 19 childhood ALL patients

No.	Case ID	Chromosome region	Aberration type	Size	Key genes
1	1	21q21.1-q22.3	Gain	48.13 Mb	RUNX1, ERG
2	4	21q21.1-q22.3	Gain	32.96 Mb	RUNX1, ERG
3	14	21q21.1-q22.3 Whole chromosome X	Gain Gain	32.20 Mb -	RUNX1, ERG -
4	17	12p13.1-p13.2	Loss	3.53 Mb	ETV6
5	25	1q23.3-q44	Gain	84.55 Mb	PBX1
6	29	9p13.1-p24.3	Loss	71.07 Mb	MLLT3, CDKN2A, CDKN2B
7	33	9p21.3	Loss	1.8 Mb	MLLT3
8	34	21q21.1-q22.3 Whole chromosome 10 Whole chromosome 18	Gain Gain Gain	48.13 Mb - -	RUNX1, ERG - -
9	40	6q13-q22.1	Loss	45.38 Mb	PRDM1, FOXO3
10	45	9p21.2-p21.3 10p11.1-p15.3 12p13.2 12q21.3-q24.3 13q12.1-q34	Loss Gain Gain Gain Gain	4.15 Mb 38.75 Mb 241.77 kb 47.15 Mb 115.17 Mb	- - ETV6 - -
11	46	12p13.2 18q11.1-q23 21q11.2-q22.3 Xp11.1-p22.3	Loss Gain Gain Gain	241.77 kb 62.75 Mb 36.99 Mb 61.89 Mb	ETV6 BCL2 - -
12	50	Xp11.21-p22.2 Xq21.3-q28	Gain Gain	48.15 Mb 60.87 Mb	- -
13	52	21q11.2-q22.3 14q11.2-q32.33 Whole chromosome X	Gain Gain Gain	36.99 Mb 106.02 Mb -	RUNX1, ERG - -
14	53	21q21.1-q22.3	Gain	25.45 Mb	RUNX1, ERG
15	55	14q11.2-q32.33 1q23.3-q44	Gain Gain	85.71 Mb 84.62 Mb	- PBX1
16	56	12p11.2-p13.3 13q13.1-q34	Loss Loss	21.46 Mb 81.9 Mb	ETV6 -
17	59	21q11.2-q22.3	Gain	48.13 Mb	RUNX1, ERG
18	61	21q11.2-q22.3 12p12.3-p13.31 Whole chromosome X	Gain Loss Gain	48.13 Mb 6.35 Mb -	RUNX1, ERG ETV6 -
19	63	Xp21.1	Loss	2.22 Mb	DMD

ISSN: 1755-8166